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KMID : 0370220040480050278
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Yakhak Hoeji
2004 Volume.48 No. 5 p.278 ~ p.284
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Pharmacokinetic Characteristics of Oral Clonazepam in Korean
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정지훈/Jeong JH
유대식/박준홍/이석용/손의동/You DS/Park JH/Lee SY/Sohn UD
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Abstract
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In order to determine the bioavailability of clonazepam, an anxiolytic drug, a simple, rapid and sensitive HPLC analysis was developed in healthy Korean volunteers. The analy sis system was validated in specificity accuracy, precision and linearity. The analysis condition we established was 2.58 min and 5 ng/ml in retention time and limit of quantitation of clonazepam, respectively, using reverse-phase Cl8 column connected to UV detector. Quantitation was performed at 235 nm wave length with p- hydroxybengoic acid ethyl ester as internal standard. The method involved a simple extraction. In order to study blood level profiles as a function of time, eight volunteers were enrolled and orally took 6 mg clonazepam once. The blood samples were collected from 0 to 120 h after the drug administration. Mean AUC and Cmax value were 1028.17±568.165 (ng/ml.hr) and 41.25±10.82 (ng/ml,respectively. And mean Tmax and T1/2 value were 1.08±0.42 (hr) and 30.78±3.26(hr). From the results we determine the pharmacokinetic characteristics of clonazepam in Korean people using a newly developed and useful HPLC method.
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